1. Where will you find a nabothian cyst? A. adjacent to the fallopian tube B. ectocervix C. endocervix D. endometrial cavity E. vulva or vaginal wall 2. Sarcoma botryoides bears markers of its origin from cells of what lineage? A. fibroblasts B. germ cells C. macrophages / facultative fibroblasts D. skeletal muscle E. smooth muscle 3. Predecidual reaction is a plumping-up of which cells? A. arterial smooth muscle of the endometrium B. endothelial cells of the endometrium C. endometrial glands D. endometrial stroma E. primitive trophoblast 4. Which is NOT a known risk factor for common adenocarcinoma of the endometrium? A. diabetes B. estrogen supplementation after menopause C. multiple pregnancies D. obesity E. ovarian thecoma, coexisting 5. Which is LEAST LIKELY to be a contributing factor to the increasing overall incidence of breast cancer? A. aging population B. later age of first pregnancy C. more obesity among women D. popularity of breast implants E. women foregoing childbearing 6. Bowen's disease of the penis is A. carcinoma in situ B. ectoparasite C. large wart without malignant potential D. mildly transmissible bacterial disease E. result of injecting lipids 7. What's the most common location for a man's adenomatoid tumor? A. corpus cavernosum B. epididymis C. glans / spongiosum D. prostate E. testis 8. Which is probably a risk factor for prostate cancer? A. alcohol abuse B. cadmium exposure C. prolonged severe abstinence D. too-frequent ejaculations E. trichomonas infection 9. What do we now know to be the cause of lichen sclerosus? A. autoimmunity as with scleroderma B. ectoparasite C. hormonal imbalances D. HPV E. mutations of the epithelial cells 10. What is the well-known common antecedent for many "mixed Mullerian tumors"? A. abortion (induced or spontaneous) B. anatomic birth defects of the uterine cavity C. diethylstilbestrol exposure D. intrauterine contraceptive device usage E. radiation therapy 11. Mutated BRCA1 is best-known for placing women at risk for cancer of the breast and A. brain B. lung C. kidney D. ovary E. sarcomas 12. TWO KODACHROMES. Ovarian tumor. What is the diagnosis? A. clear cell carcinoma B. dermoid cyst C. endometrioid carcinoma D. serous cystadenocarcinoma E. Stein-Leventhal 13. ONE KODACHROME. Prostate. What is the diagnosis? A. adenocarcinoma, cribriform B. adenocarcinoma, well-differentiated C. benign hyperplasia D. prostatitis, mostly acute E. uh, this is seminal vesicle 14. ONE KODACHROME. Pelvic tissues. What is the diagnosis? A. actinomycosis B. adenocarcinoma of endometrium C. endometriosis D. gonorrhea or other pelvic inflammatory disease E. metastatic serous ovarian cancer 15. ONE KODACHROME. Endocervix. What is the diagnosis? A. adenocarcinoma B. HPV effect and dysplasia C. microglandular hyperplasia D. squamous metaplasia without atypia E. no pathology 16. ONE KODACHROME. Prostate. What is the diagnosis? A. benign prostatic hyperplasia, or normal B. cribriform adenocarcinoma C. infarct D. prostatitis, mostly acute E. well-differentiated adenocarcinoma 17. TWO KODACHROMES. Ovarian tumor. Give your best guess for the histology. A. choriocarcinoma B. dermoid cyst C. mucinous cystadenoma D. serous cancer E. thecoma 18. ONE KODACHROME. Testicular tumor. Your best diagnosis? A. choriocarcinoma B. embryonal cell carcinoma C. Leydig cell tumor D. seminoma E. uh, this is tuberculosis 19. ONE KODACHROME. Breast lesion. What is the diagnosis? A. colloid carcinoma B. comedocarcinoma C. medullary carcinoma D. scirrhous cancer E. tubular carcinoma 20. ONE KODACHROME. Uterus. Guess the diagnosis just based on the gross appearance. A. adenocarcinoma of the endometrium B. adenomyosis C. choriocarcinoma D. gas gangrene E. leiomyoma 21. ONE KODACHROME. Ovarian tumor. Which kind? A. Brenner tumor B. dysgerminoma C. endometrioid adenocarcinoma D. mucinous cystadenoma E. serous cystadenocarcinoma 22. TWO KODACHROMES. Uterus. What is this? A. actinomycosis B. adenocarcinoma of the endometrium C. benign endometrial polyp D. cystic endometrial hyperplasia E. leiomyoma of uterus 23. TWO KODACHROMES. Endocervix. What is the diagnosis? A. acute cervicitis, consistent with gonorrhea B. carcinoma in situ C. HPV effect without atypia D. microglandular hyperplasia E. uh, this is normal squamous / normal squamocolumnar junction 24. ONE KODACHROME. Testis. What is the diagnosis? A. choriocarcinoma B. embryonal cell carcinoma C. infertility with Sertoli-only D. Leydig cell tumor E. seminoma 25. ONE KODACHROME. Breast cancer. What subtype? A. colloid / mucinous carcinoma B. papillary carcinoma C. scirrhous carcinoma D. tubular carcinoma E. uh, it is a benign fibroadenoma 26. TWO KODACHROMES. Testicular cancer. What is the diagnosis? A. choriocarcinoma B. embryonal cell carcinoma C. malignant lymphoma D. seminoma E. uh, this is tuberculosis 27. ONE KODACHROME. Breast cancer. Which subtype? A. comedocarcinoma B. ductal carcinoma in situ C. medullary carcinoma D. scirrhous carcinoma E. uh, this is normal post-menopausal breast 28. ONE KODACHROME. Ovarian tumor. What kind? A. choriocarcinoma B. granulosa cell tumor C. dysgerminoma D. serious cystadenocarcinoma E. Sertoli-Leydig cell tumor 29. TWO KODACHROMES. Breast. Make the diagnosis. A. comedocarcinoma B. gynecomastia C. pregnant, nothing else wrong D. scirrhous carcinoma E. tubular carcinoma 30. TWO KODACHROMES. Ovary. What should we to call it? A. Brenner tumor B. choriocarcinoma C. dysgerminoma D. granulosa cell tumor E. serous cystadenocarcinoma BONUS ITEMS: 31. ONE KODACHROME. Testis. Your best diagnosis? 32. ONE KODACHROME. Whether or not you did the "Pap Smear" option, you can probably figure this one out! 33. An acardius is a child born with no heart. How could such a child survive the nine months of intrauterine life? No lawyer jokes please. 34. You'll be surprised how often somebody will ask you the karyotype of a partial hydatidiform mole. Give a common one. 35. What disorder of the female genital system is likely to cause spectacular swelling of the endothelial cells of the glomeruli? 36. What's the term we give to a placenta which overlies the lower uterine segment and is ripped free as the cervix dilates? NAME: ________________________ 30 points maximum UHS-COM Reproductive System 2001-2002 Pathology Practical Instructions: Please stay in your seats through this exam. The pictures will be shown twice in each room. After the second showing in the first room, the key will go up. If you have a question, please raise your hand. Do NOT phonate! Good luck!