Nucleoli are the organelles in the nucleus where ribosomes are made.
Although most eukaryotic cells have at least one nucleolus, you can only see them on light microscopy if they are relatively large. This means that the cell is planning to make a lot of protein.
Nucleoli appear sharply demarcated within the surrounding nucleus. They will stain slightly more eosinophilic than the heterochromatin under the nuclear membrane.
Except in some cancer cells, nucleoli are always round.
This is a section of brain with an especially large nerve cell ("neuron") in the middle.
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